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Du 2 au 4 Octobre 2009

Le LEM participera au forum de la Terre du 2 au 4 Octobre 2009, au château d'Haroué.

Pour plus de renseignements concernant cette manifestation, consulter le site du

forum de la Terre.

15 Septembre 2009

Vol. 25, Iss. 18 Cover illustration by Jérôme Duval. The study demonstrates the effects of proteolytic papain and protease-free neuraminidase enzymes on the electrohydrodynamic (electrokinetic) properties of human red blood cells and their propensity to agglutinate via immunoglobuline G (IgG) anti-D antibody binding. A significant reduction of the hydrodynamic permeability and thickness of the external glycoprotein layer of the soft erythrocytes is reported under the action of papain, in line with a loss of cell surface integrity highlighted by nanomechanical AFM analysis. Neuraminidase treatment basically leads to an important decrease of the cell charge density with modulations of the hydrodynamic softness that remain less significant than those for papain-treated cells. On the basis of these interfacial characteristics, the overall interaction potential profiles between two native cells and two enzyme-treated cells are theoretically evaluated. In agreement with IgG agglutination data, it is found that blood cell agglutination is promoted to a larger extent by a decrease of steric glycoprotein layer thickness than by a decrease in interphasial cell charge density. For more information, see "Impacts of Papain and Neuraminidase Enzyme Treatment on Electrohydrodynamics and IgG-Mediated Agglutination of Type A Red Blood Cells " by Atsushi Hyono, Fabien Gaboriaud, Toshio Mazda, Youichi Takata, Hiroyuki Ohshima, and Jérôme F. L. Duval on pages 10873-10885 of this issue. View the article.

Mars 2009

Odile Barrès (IR) est lauréate du CRISTAL DU CNRS.
Cette distinction est décernée annuellement aux 15 meilleurs ingénieurs, techniciens et personnels administratifs du CNRS, tous départements confondus.

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